Bidirectional Brain-Body Interactions and Refinement of Multidimensional Electrical Neuromodulation for Enhanced Living- IRENE (2024 – 2027). Reference: PID2023-149837OB-I00. Funded by MICIU, AEI & FEDER, total: 138.250 € P.I. Ivan Contreras. Other participants: IDIBGI, FUNDACIÓ DE RECERCA CLÍNIC BARCELONA & UNIVERSITY OF CAMBRIDGE.
SUMMARY:
The IRENE project positions itself as an innovative initiative focused on the research and application of non-invasive vagus nerve stimulation (nVNS). Continuing the research path initiated by the VaNeSA project (PID2020-117171RA-I00), the IRENE project explores new solutions involving personalized nVNS to enhance the treatment and self-management of different disorders by stimulating the autonomic nervous system (ANS). To expand on the research conducted in the VaNeSA project, our first step involves the validation of a decision support system (DSS) that integrates computational models specifically tailored for systemic lupus erythematosus (SLE) patients.
This extension aims to improve the scope and applicability of our investigations.
Secondly, in response to the growing need for more refined and personalized approaches to combat obesity, IRENE proposes to characterize nVNS parameters, validate computational models, and explore personalized therapies based on these findings. Additionally, we will integrate data from VaNeSA and other studies to investigate the role of heart rate variability (HRV) and compare treatments to analyze differences and seek the generalization of a therapeutic model capable of tailoring nVNS treatments according to the disease characteristics.
Finally, with a focus on technological innovation, IRENE also embarks on the development of advanced hardware for nVNS. The ultimate
goal is to provide a solid scientific basis for advancing the understanding of nVNS treatments, advocating for a comprehensive and patientoriented
perspective. The execution of clinical trials is crucial for the success of the project. Initially, one exploratory study will be undertaken to characterize the impact of nVNS therapy on patients suffering from obesity in free-living conditions. Additionally, a proof-ofconcept outpatient clinical evaluation of the DSS with patients suffering from SLE will validate the scientific results and will consolidate the technology to higher technological readiness levels.
Founded by MICIU/AEI/10.13039/501100011033 and FEDER, UE
TEAM:
MICELAB:
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Research leads:
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Research Team:
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FUNDACIÓ INSTITUT D`INVESTIGACIÓ BIOMÈDICA DE GIRONA DR. JOSEP TRUETA (IDIBGI)
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FUNDACIÓ DE RECERCA CLÍNIC BARCELONA-INSTITUT D’INVESTIGACIONS BIOMÈDIQUES
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UNIVERSITY OF CAMBRIDGE
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RESEARCH OUTCOMES:
- Personalized Neuromodulation Therapy: Development of computational models and hardware for non-invasive vagus nerve stimulation (nVNS) tailored to individual patients with obesity and SLE for enhanced treatment outcomes
- Decision Support System (DSS): Creation of a mobile-based DSS integrated with HRV biomarkers and real-time data to provide adaptive, patient-specific nVNS therapy recommendations.
- Clinical Validations and Impact: Validation of nVNS hardware and DSS in clinical trials, demonstrating improved autonomic nervous system function, reduced symptoms and enhanced quality of life for patients.